Patrick D.  Lyden, M.D.

Patrick D. Lyden, M.D.

Dr. Patrick D. Lyden is a neurologist who is currently affiliated with Cedars-Sinai Marina del Rey Hospital. He received his medical degree from the Baylor College of Medicine and completed his residency at the University of California, San Diego School of Medicine. The physician has done extensive research on the subject of translational stroke and has published numerous papers on various subjects regarding the science of neurology. His work has been recognized with numerous awards and Dr. Patrick D. Lyden is a member of multiple associations, such as the American Heart Association, the American Neurology Association, and the Society for Neuroscience. In 2020, he joined the faculty of the Keck School of Medicine of USC as a Professor of Physiology and Neuroscience and of Neurology, as well as a Zilkha Scholar within the USC Zilkha Neurogenetic Institute.

As a recognized global leader in stroke therapy, Dr. Patrick D. Lyden led a landmark clinical study in 1995 that resulted in the approval of the first treatment for stroke, which involves the intravenous delivery of engineered protein that breaks down blood clots. The neurologist also played a crucial role in refining the National Institute of Health Stroke Scale, a widely used tool for evaluating the severity of a stroke. He produced and directed training and certification videos about the scale that have been viewed almost 2 million times by health care providers around the world. The co-author of over 350 peer-reviewed papers and book chapters, Dr. Patrick D. Lyden has received research funding from federal agencies constantly for over 30 years. He is advancing a new approach to stroke treatment by using agents that target multiple biochemical pathways at the same time. His studies delve into the toxic effect on brain cells of thrombin, the enzyme that helps the blood clot, as well as the therapeutic possibilities of blocking that enzyme.

Insurance Accepted

  • Aetna Choice POS II
  • Cigna
  • First Health PPO
  • Great West PPO
  • HealthNet
  • Multiplan PPO
  • United Healthcare

Languages Spoken

  • English

Education & Training

Medical Degree

Baylor College of Medicine


Mercy Hospital and Medical Center


University of California, San Diego School of Medicine


University of California, San Diego School of Medicine

Memberships & Affiliations

  • American Heart Association American Heart Association
  • Publications & Media