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Is an adrenal tumor a genetic problem?

No, most adrenal tumors are not genetic.

Most adrenal tumors are sporadic, not due to an inherited genetic problem. However, there are some types of adrenal tumors that are associated with certain genetic syndromes such as Li-Fraumeni syndrome, Beckwith-Wiedemann Syndrome, Von Hippel-Lindau syndrome, and Carney complex.

Patients with Li-Fraumeni syndrome have a higher risk of many cancers including breast cancer, soft tissue sarcomas, brain tumors, osteosarcoma, leukemia, and adrenal cancer.

Beckwith-Wiedemann syndrome is caused by a mutation in the gene that controls the production of a protein. The overproduction of this protein can also be found in sporadic adrenal cancer. Researchers believe that too much of this protein causes tumor cells to grow abnormally. Several clinical trials are in progress to treat adrenal cancer with drugs that block this biochemical pathway.

Von Hippel-Lindau syndrome is associated with a type of tumor, which typically occurs in the adrenal glands.

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Source: https://www.cedars-sinai.edu/Education/Medical-Library/